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The up-regulation of MHC-II at the peak of demyelination may be of relevance for the induction of remyelination since MHC-II / mice showed delayed remyelination and regeneration of oligodendrocytes after cuprizone-induced demyelination (Arnett et al., 2012)

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In a mouse model, metformin was able to reduce HFD-induced hepatic steatosis and adipocyte inflammation by reducing cytokine expression and increasing colonic mucus production [221]