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Additionally, ABCC1 is found to be indirectly upregulated by the silenced CUL3 KEAP1 E3 ligase in breast cancer, stabilizing nuclear factor erythroid 2-related factor 2 (NRF2), and subsequently increases NRF2-regulated ABCC1 transcription, which exhibits resistance to both doxorubicin and paclitaxel [64]

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doi: 10.22038/ijbms.2019.30588.7372 102 AzarbarzNShafiei SeifabadiZMoaiediMZMansouriE