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DON treatment activates AMPK in cancer cells by increasing the AMP/ATP ratio and decreasing the expression of c-Myc proteins, thereby inhibiting glycolytic metabolism and suppressing cancer cell growth in vitro 145

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While the activity of I 1 r Pf GS was comparable with r Pf GS when exposed to higher concentrations of urea or NaCl (Supplementary Fig

it just makes the solution more dilute, which can sometimes make it easier to measure smaller doses accurately

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