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Conversely, loss of the RB1 gene upregulates the expression of GLS and SLC1A5 genes, further promoting cellular uptake and utilization of glutamine [111]

Oxidative modifications of DNA result in base alterations, formation of single- and double-strand breaks, sister chromatid exchanges and translocation in replicating cells, as well as formation of DNA-DNA and DNA-protein cross-linking (50)