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This treatment exhibited, on average, high concentrations of curcuminoids, a high concentration of total phenolics, and high values for both antioxidant activity (DPPH and ABTS) and in vitro biological activities (AChE and LOX inhibition)

In the cecal ligation and puncture (CLP) paradigm, which simulates sepsis-induced ALI, luteolin treatment dramatically decreased lung inflammation, oxidative stress, and histological damage [96], followed by improvement in immune modulation by boosting Treg and IL-10 levels [255]

Lipoylation occurs on a single lysine residue within the OGDHc-E2, K110, and we observed that ML226 treatment decreased levels of the functional K110 lipoate moiety by LCMS (Fig