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The authors have demonstrated that natural extract containing 9 -THC decreased the TAGs content and improved the glucose uptake in the insulin resistant 3T3-L1 cells in a concentration-dependent manner ( 9 -THC, which also improved sensitivity of the cells to insulin ( 9 -THC treatment enhanced glucose transporter type 4 (GLUT4) and insulin receptor substrate 1 and 2 (IRS-2) gene expressions, which play key roles in the insulin signaling pathway ( Figure 1 On the other hand, in comparison to the well-documented orexigenic effect of 9 -THC, many studies have also shown a potential anti-obesity effect of this phytocannabinoid derivative

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