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doi: 10.1016/j.freeradbiomed.2009.05.032 60 OverstreetD

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1 Introduction Periodontitis is a chronic inflammatory disease triggered by dental plaque that leads to progressive destruction of periodontal supporting tissues, clinically manifested as gingival inflammation, periodontal pocket formation, alveolar bone resorption and tooth loosening and eventual loss ( Ferroptosis is an iron-dependent form of programmed cell death characterized by phospholipid peroxidation and plasma membrane damage

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