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Description

For observational studies in Table 1 ( n = 11), formal standardized risk of bias assessment was not conducted due to substantial heterogeneity in study designs, participant characteristics, laboratory methods, and outcomes measured

B.KolencD.AralicaG.MisicM.et al (2014)

It was first developed during research into the pineal gland, a small structure in the brain involved in regulating the bodys sleep-wake cycle and the production of melatonin, among other things