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Mechanisms of oxidase and superoxide dismutation-like activities of gold, silver, platinum, and palladium, and their alloys: a general way to the activation of molecular oxygen

Jama 2023;329:1558-1566

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Strengths and Limitations Strengths: Rigorous double-blind, placebo-controlled design Use of validated outcome measures Low dropout rate Demonstrated feasibility and safety Limitations: Small sample size (n=34) Limited generalizability High placebo effect, common in FMS research Short follow-up duration (only 4 weeks post-treatment) Context in FMS Treatment Current pharmacological options for FMS include NSAIDs, tramadol, pregabalin, and antidepressants, but these often have modest efficacy and undesirable side effects