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Despite its beneficial roles, excessive production of NO can lead to its reaction with superoxide to form peroxynitrite (ONOO ), a potent oxidizing and nitrating agent [31]

It is also worth noting that glutathione levels decline with age, starting from around the age of 50

(2S,2'S)-5,5'-(2R,2'R)-3,3'-disulfanediylbis(1-(carboxymethylamino)-1-oxopropane-3,2-diyl)bis(azanediyl)bis(2-amino-5-oxopentanoic acid)

In vivo studies demonstrated that, individually or combined, cannabinoids may reduce tumor growth or tumor cell proliferation and promote apoptosis and autophagy in melanoma cells, emerging as potential agents for the treatment of cutaneous melanoma [55]

as a result, they may compete with essential metallic cofactors for entry into cells and incorporation into enzymes