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As a result, these in vitro culture approaches that predominantly exhibit the activated (aVIC) phenotype may not reliably represent the process of VIC activation or the characteristics of a healthy valve

Regarding plasma metabolites and PTs, no evidence of heterogeneity was observed across the seventeen types of plasma metabolites

Postmortem studies of PD brains have demonstrated microglial activation in the substantia nigra pars compacta (SNpc), characterized by increased expression of markers such as HLA-DR, CD68, and Iba-1, along with elevated production of pro-inflammatory mediators including IL-1, TNF-, IL-6, and reactive oxygen species (ROS) [73]

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doi: 10.3390/antiox9020116 74