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Consistent with this hypothesis, we found that suppression of fork reversal by ZRANB3 depletion prevented micronucleation induced in U2OS cells by low doses of hydroxyurea (HU) or aphidicolin (Supplementary Fig

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It occurs when the impact strikes the precordial region during a critical phase of the cardiac cycle (the up-slope of the T-wave, about 1040 ms before its peak)