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Non-cancer epidemiology 8.3.2

Gene therapy and emerging approaches Emerging gene therapy approaches further expand the therapeutic landscape

Importance: Reduces dropout in sensitive cohorts

While some human studies have reported the potential effects of a single dose of oral glycine to reduce glucose excursion or increase insulin secretion 23,42 , other studies using oral or intravenous glycine failed to demonstrate any response 43,44

Recently, a new isoprenylated sanggenon-type flavanone, nigrasin K, along with some other analogs including sanggenon M, C and O, chalcomoracin, sorocein H and kuwanon J isolated from the twigs of Morus nigra have been identified as potent tyrosinase inhibitors by Hu et al