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In response to certain environmental toxins and endogenous proteins, microglia can shift to an over-activated state and release ROS which can cause neurotoxicity (Surace and Block, 2012)

The brain-heart axis: integrative cooperation of neural, mechanical and biochemical pathways

Absolute configuration of the enantiomers previously dissolved in a 1 :1 mixture of heptane/ethanol and allowed to slowly evaporate for 1 week to induce the formation of crystals) was confirmed by x-ray crystallography