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Fatty liver, in which fat is deposited in the liver tissue, is thought to progress to non-alcoholic steatohepatitis and liver cirrhosis (NASH) when the tissue is exposed to certain stimuli such as oxidative stress and inflammatory cytokines

In brief, the numbers of MDSCs significantly increase with aging both in the circulation of humans and mice [127, 128]

60 The rise in the serum levels of pro-inflammatory cytokines are also observed in SARS-CoV and MERS-CoV infection, suggesting a potentially similar cytokine storm-mediated disease severity