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Froger N, Moutsimilli L, Cadetti L, Jammoul F, Wang Q-P, Fan Y, et al

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2,3 Rats, for example, synthesize AA at a rate of about 70 mg/kg of body weight per day at baseline versus 215 mg/kg per day when stressed

FIGURE 2 ROS-Dependent Mechanism of Iron Neurotoxicity Iron accumulation in the NS is a common feature in neurodegenerative diseases, including Alzheimers disease (Connor et al., 1992), Parkinsons disease (Gorell et al., 1995), Huntingtons disease (Dumas et al., 2012) or amyotrophic lateral sclerosis (Kwan et al., 2012)