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Although there is little evidence of interaction between iGluRs and mGluRs receptors, a dynamic interaction between the C-terminal domain (CTD) of mGluR5 and NMDAR (GluN1a/2B) receptors have been reported in the human embryonic kidney (HEK) 293 cells using bioluminescence resonance energy transfer (129)

J Am Acad Dermatol 52(6):10821084

Cognitive effects could possibly depend on baseline nutritional status, i.e., any benefits of micronutrient supplementation might only be realized in individuals with micronutrient deficiencies and not in those with adequate micronutrient status