how long for vitamin b12 injections to work Injection: Benefits, Uses and Who Needs It How Long Does a B12

Lau et al

DOSAGE AND ADMINISTRATION For Intramuscular administration: General: Twice daily 1 ml per 20 - 40 kg body weight for 3 days

If there is clinical improvement and if a reticulocyte response is observed, the same amount may be given on alternate days for seven doses, then every 3 to 4 days for another 2 to 3 weeks

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Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation