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Tacrolimus is a powerful immunosuppressant primarily used to prevent organ transplant rejection and treat certain autoimmune conditions

Genome Research

The ingredients could act through two possible ways: (a) biological mechanism-oriented by exerting anti-photodamage actions, namely the products resulting of the direct and oxidative damage of DNA, downregulation the expression of MMPs, and pro-inflammatory cytokines confirmed in in vitro studies in keratinocytes and fibroblasts and in vivo and ex vivo studies, and/or (b) clinical effects-oriented by softening the visible effects of the skin sun damage, by providing moisturizing effect and refreshing properties, mainly corroborated by clinical trials

SSG also negatively regulates autophagy

After extensive experiments, MC3181 was deemed the more promising compound of the two, due to it having a 50-fold rise in aqueous solubility and higher selectivity toward GST