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Moreover, the brains rich content of metal ions, such as iron, facilitates oxidative stress and DNA damage through the Haber-Weiss reaction (Suma et al., 2020), and promotes the aggregation of -synuclein, leading to the formation of Lewy bodiesa key pathological feature of PDD and Lewy body dementia (Wakabayashi et al., 2007)

Recent molecular and cellular studies show that when vascular endothelial cells or tissue stem/progenitor cells die, additional reactive pathways are set off, leading to even more significant cell loss, tissue damage, fibrosis, necrosis, and impairments in function [27]

This spectrum of disorders is characterized by varying levels of deficits in social behavior and communication, as well as stereotypical behaviors ( In addition to behavioral deficits, autistic individuals often present with mild systemic inflammation and gastrointestinal disorders ( The exact mechanisms underlying the increased production of pro-inflammatory cytokines and allergy-associated Th2 cytokines in autistic individuals are yet to be elucidated

Malondialdehyde-acetaldehyde antibody concentrations in rheumatoid arthritis and other rheumatic conditions

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