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Studies in the past 15 years have elucidated the molecular signaling pathways that regulate GCL expression

Cats and dogs possess a combined repertoire of at least 27 cytosolic glutathione transferases belonging to the GST-A, -M, -P, -T, -Z and -O classes, with the greatest genetic diversity observed for the GSTA, GSTM, GSTP, and GSTT classes

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Prognosis may be variable, depending on the degree of clinical involvement, particularly the degree and duration of metabolic acidosis and the effectiveness in preventing overwhelming sepsis

Changes in GSH levels with time post dose were calculated as the difference in GSH/Cr peak ratios for each subject at each time point (GSH/Cr post dose GSH/Cr baseline ), or similarly, the difference in absolute GSH for each subject at each time point