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Next to pharmacological or NAD + precursor modulators, it is possible to raise NAD + levels through exercise 302,306,307 , however, not all preclinical studies investigating exercise have linked increased NAD + levels to mitochondrial function

Vitamin B12 is responsible for making red blood cells, white blood cells, and platelets

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The mechanism centers on beta-3 adrenergic receptors in adipose tissue

Another study published in the Journal of Psychopharmacology found that B12 supplements improved mood and reduced symptoms of depression in individuals with depression