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Acknowledgements Not applicable Funding No funding Ethics declarations Ethics approval and consent to participate This animal experiment was approved by the ethics committee on the experimental use of laboratory animals of the Asan Medical Center Animal Research Committee

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Extensive studies have demonstrated that DNA methylation can exert an impact on the escape of tumor cells from the immune surveillance through modulating the transcription of immune checkpoint molecules

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Drug testing helps the doctor in evaluating the patients drug history as well as aids them in avoiding or minimizing a possible reaction to other medications or narcotics