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Dose-dependent increase in oxidative stress in Leydig cells leading to cytotoxicity, cell death, and impaired gonadal function

For instance, Chaigui granules demonstrated notable antidepressant effects in a CUMS model

(106) included seven randomized, placebo-controlled trials that exclusively enrolled individuals with high blood pressure, i.e., with systolic blood pressure (SBP) 140 mm Hg and/or diastolic blood pressure (DBP) 90 mm Hg

This is also consistent with earlier studies showing that cystine starvation activates GCN2 rather than PERK 47 and the lack of enhanced splicing of the XBP1 mRNA upon erastin treatment 9

Pfister, B