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Specifically, weight gain has been associated with both INSTI and TAF use in both clinical trials and real-world observational studies [5, 31,32,33,34], while weight loss has been associated with use of TDF and EFV [2,3,4]

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The term aryl refers to an aromatic group having at least one carbocyclic aromatic group or heterocyclic aromatic group, which may be unsubstituted or substituted by one or more groups selected from halogen, haloalkyl, hydroxy, alkoxy, carbonyl, alkylamido, nitro, amino, dialkylamino, carboxy, thio or thioalkyl

2004 Oct 1;94(2-3):219-43

[6] In summary, aside from hypersensitivity, the use of pyridoxine should be guided by clinical necessity, and caution exercised in populations vulnerable to potential risks of excipients or overdose