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2 Acetaminophen may exert an inhibitory action on the synthesis of nitric oxide at the spinal level, which in turn may interfere with nociception via spinal NMDA receptor activation

On the other hand, persons with significant atherosclerotic heart disease may not tolerate any increase in T3 levels/effects due to increased cardiac work and resultant worsening of angina or triggering of arrhythmias

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.James S.J., Cutler P., Melnyk S., Jernigan S., Janak L., Gaylor D.W., Neubrander J.A

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