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Description

Untargeted lipidomics highlight the depletion of deoxyceramides during therapy-induced senescence

Teh MR, Armitage AE, Drakesmith H

We find that each phospho-null mutation within the GAP-F5 protein significantly yet partially reduces G2019S LRRK2-mediated phosphorylation relative to WT GAP-F5, however, none of these three residues serve as a dominant phospho-site as they have equivalent effects ( Fig