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found that ATP levels were significantly decreased in HL-60 and OCI-AML3 cell lines in the presence of 1 M CB-839 for 72 h

second, developing therapeutic strategies to modulate mTOR activity in a wide range of human diseases 22 (Fig

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Individuals consuming high-beef diets have increased populations of phenol-producing anaerobic Bacteroides compared to individuals on vegetarian diets.8788 Comparisons of western and eastern populations indicated that individuals who consume a typical British and American high-meat diet have a higher ratio of anaerobic to aerobic microflora than persons from Japan, Uganda or India, whose diets are largely vegetarian.89 These findings were confirmed in a study of volunteers who adopted a strictly vegan diet which led to a decrease in serum and urinary phenol and p-cresol concentrations.59 Upon returning to a conventional diet that included the addition of meat and eggs, the volunteers urinary phenol and p-cresol concentrations correspondingly increased.59 Substitution of carbohydrate for protein may not be the only factor responsible for the reduction in phenol levels seen in vegetarians

Acta Biol Szeged 46:5556 Thatcher LF, Carrie C, Andersson CR, Sivasithamparam K, Whelan J, Singh KB (2007) Differential gene expression and subcellular targeting of Arabidopsis glutathione S-transferase F8 is achieved through alternative transcription start sites