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The Fecal Microbiota Transplantation to Improve Efficacy of Immune Checkpoint Inhibitors in Renal Cell Carcinoma (TACITO, NCT04758507) 52 study is an investigator-initiated, randomized, double-blind, placebo-controlled phase 2a clinical trial designed to determine whether donor FMT from complete ICI responders can enhance the effectiveness of first-line pembrolizumab plus axitinib therapy in patients with mRCC

J Biol Chem (2013) 288(32):228938

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However, LCACs also modulate the activity of specific ECC ion channels and enzymes