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The activation of BK Ca channels by H 2 S is mediated via TRPV4 channels and subsequent Ca 2+ influx ( 2 S-producing enzymes CBS and CTH increases in the epididymis from the caput to the cauda epididymis, corresponding to the increasing production of endogenous H 2 S ( + concentration in rat intraluminal fluid also increases from the caput to the cauda, which supports the idea that H 2 S increases K + secretion ( 2 S is probably in reducing sperm motility by increasing the extracellular concentration of K + ions, keeping them in a quiescent state before ejaculation ( H 2 S production has also been described in vas deferens ( 2 S-producing enzymes have been detected in the prostate, with the highest abundance of CTH, which is likely the main H 2 S producer in this tissue ( 2 S in the vas deferens and prostate is primarily to relax smooth muscle ( 2 S also plays an important role in the detection and treatment of prostate cancer