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Dose-dependent phorbol ester facilitation or blockade of hippocampal long-term potentiation: relation to membrane/cytosol distribution of protein kinase C activity

Patients received standard therapy with a GH dose identical to each subject's prestudy therapy, with median 33 (range 1346) mcg/kg/d

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Recent PD diagnostic tests have focused on elevated cerebrospinal fluid (CSF) levels of the -synuclein (-Syn) protein or reduced blood mitochondrial DNA as biomarkers 11,12,13,14

Understanding the mechanism driving epigenetic deregulation can shed light on potential therapeutic targets and is an intensive area of research in mutant H327M DIPG