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Also in this setting, the potency of FOXO4-DRI was more pronounced when applied in consecutive rounds Not only did FOXO4-DRI selectively target the senescent cells, but it was also effective agains the induced chemo-toxicity observed in the form of liver toxicity and body weight loss

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213,216 NAD + -dependent modification of metabolic enzymes Beyond serving as a hydride-donating coenzyme for metabolism, NADH/NAD + also acts as co-substrate for the sirtuins-mediated post-translational modification of metabolic enzymes including acetylation, ADP-ribosylation, succinylation and malonylation