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doi: 10.1016/j.neuint.2023.105646 34 MaasA

Research using Morris water maze (spatial memory), passive and active avoidance (fear-motivated learning), novel object recognition, and operant conditioning tasks shows that Semax improves acquisition, consolidation, and retrieval of memory in both normal animals and those with experimentally induced cognitive impairment

In rat models of PD, IN DFO has been reported to protect dopaminergic neurons in the substantia nigra and ameliorate motor deficits, suggesting IN DFO reaches the midbrain regions at pharmacologically active concentrations (Febbraro et al., 2013)

This is accompanied by a reduction in both granulocytic and monocytic MDSCs, highlighting the potential of 2-AR inhibition to impair MDSC function and alleviate immunosuppression in the TME

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