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Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons

NF-B serves as a regulatory hub for numerous inflammatory genes, amplifying monocyte chemoattractant protein-1 (MCP-1) expression, particularly in renal mesangial and tubular endothelial cells

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Research indicates that supplementing with both calcium and vitamin D improves inflammatory markers, insulin sensitivity, and menstrual regularity in women with PCOS, supporting its inclusion as a physiologically significant micronutrient (40)