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Heavy smokers and drinkers can also have low levels of B12

This receptor-level distinction is what mechanistically separates the two, despite both falling under the broader category of growth hormone secretagogue research

Secondary causes of HTG can also include T2DM, hypothyroidism, pregnancy, hepatosteatosis, significant weight re-gain after weight loss, nephrotic syndrome and some medications [1, 4, 12]

Interestingly, in healthy men, low dietary Se intake (13 g/day for ~100 days) decreased serum, erythrocyte, and seminal plasma (but not sperm) Se concentrations, without influencing serum androgen, LH, and FSH concentrations, and decreased concentration and total number of sperm, increased the proportion of tailless sperm, but decreased the proportion of headless sperm (185)

2023;38(13):e102