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Any references to biological effects are based solely on experimental and preclinical data

Alzheimers Disease Progressive in nature Emotions such as agitation, apathy, anxiety, and depression are often present Characterized by loss of function to perform daily activities such as driving, grocery shopping, dressing, self-feeding Has no known cure Vascular Dementia More common in men Often occurs concurrently with Alzheimers A typical sign in a disturbance in gain The person is often more child-like and dependent Has an abrupt onset which means a very noticeable decline in daily function will be obvious in a short period of time Lewy-Body Dementia Speed of thinking is slow Course of symptoms fluctuate which means the persons best ability to function may vary day to day Usually present with hallucinations and signs of parkinsonism

Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity

Nature 452 , 887891 (2008)