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Although spatial multiomics and single-cell omics techniques can provide a deeper understanding of tissue and cellular heterogeneity, elucidation of the molecular and phenotypic heterogeneity in disease pathways underlying diabetic complications and the complex interplay of risk factors, such as obesity, aging, and inflammation, poses significant challenges to the discovery of biomarkers and the development of standardized therapeutic strategies

Along with this, cerebrovascular accident (CVA) is currently the second leading cause of death in the Western world, ranking after heart disease and before cancer [337], and experts predict that it is likely to be soon the most common cause of death worldwide [338]

Protein oxidation: Protein carbonyl groups serve as reliable biomarkers of protein oxidation

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The low-risk group exhibited high expression of GLS, LIPT1, ATP7A, and ATP7B, as well as increased immune infiltration and sensitivity to immune checkpoint inhibitors (176)