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The body needs time to adapt to each dose level, and GI side effects (nausea, decreased appetite, occasional diarrhea) tend to peak within the first 1-2 weeks of a new dose and then diminish

Wayne Dailey sat in a waiting area at a Houston hospital, anxious for word about his wife

That result, combined with the Phase I data showing measurable neurogenic effects in healthy volunteers at 40 mg daily, is what puts it in the advanced nootropic conversation

Other mechanisms, including vasodilatation with changes in local capillary blood flow, have been postulated to account for part or all of the antidotal action of sodium nitrite (Way et al., 1984

Stomach issues, such as gastritis, infection with Helicobacter pylori or bariatric surgery (reducing stomach size) can all significantly reduce B12 absorption (Sobczyska-Malefora et al., 2021)