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Pathway analysis of metabolomic data may be misleading due to lower coherence of metabolite levels in linear biosynthetic pathways, rapid transport of metabolites to and from their sites of synthesis, frequent circulation and exchange of metabolites between organs, and tissues, changes in a given metabolite may be due to multiple pathways, and bioinformatic limitations and unique analytical constraints of metabolites 57

gRNA sequences (Supplementary Table 33) were obtained from Synthego and oligos with 5 overhang for cloning into lentiCRISPRv2 were manufactured by Thermo Fisher Scientific

Inflammatory bowel diseases (IBD) and the microbiome-searching the crime scene for clues

Endpoints in NASH clinical trials: are we blind in one eye

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