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TZ slows or prevents neuronal loss, increases dopamine levels and partially restores motor function in MPTP mouse model, 6-OHDA rat model, and rotenone Drosophila model of PD, by potentiating PGK1 activity, enhancing glycolysis, and increasing cellular ATP levels

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Levels of MDA or total cysteine were not impacted by GlyNAC supplementation compared to placebo, although a moderate but significant intra-individual lowering of total cysteine levels was observed at the highest dose (means, 7.2 g, start of study = 415.9, end of study = 396.7 mol/L, p -value = 0.028) (Supplementary Table S4)

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