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Morris V, Janku F, Huang H, Fu S, Overman M, Piha-Paul S, Subbiah V, Kee B, Tsimbierdou A, Fogelman D, Shurieqi I, Manuel S, Scamardo A, Lanman R, Sommer N, Hong D, Kopetz S

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In addition, DTSS NPs are formed by co-assembling salinomycin with thymopentin (TP5) and the ER-targeting photosensitizer s-780 and modified with DSPE-PEG-biotin, and the high heat and ROS generated by s-780 further induce ER stress thereby downregulating PD-L1 expression and activating the cGAS-STING pathway, while the loaded TP5 significantly promotes the proliferation and differentiation of T cells thereby enhancing anti-tumor immunity and inhibiting cancer metastasis and recurrence (232)

Nrf2 induces Ucp1 expression in adipocytes in response to 3-AR stimulation and enhances oxygen consumption in high-fat diet-fed obese mice