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Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

However, the concentration, absorption, bioavailability, and pharmacokinetics of polyphenols can pose challenges to their beneficial effects against neoplastic diseases

Terzi A, Roeder H, Weaver CJ, Suter DM (2020) Neuronal NADPH oxidase 2 regulates growth cone guidance downstream of slit2/robo2

Clinical trials have demonstrated that 1% forskolin eye drops significantly reduce IOP in patients with open-angle glaucoma, offering a potential alternative or adjunct to traditional treatments (223)

Importantly, longitudinal studies assessing safety, delivery optimization, and immune tolerance will be critical for clinical development