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In summary, this study demonstrates that calcium overload plays a critical role in the cytotoxicity associated with a-synucleinopathy, leading to mitochondrial damage, lysosomal dysfunction, and cell death

One mechanism that contributes to cytochrome c detachment from IMM involves cardiolipin oxidation because oxidized cardiolipin has a much lower affinity for cytochrome c than the reduced form

A Therapeutic Use Exemption (TUE) allows a WADA-tested athlete to use a prohibited substance for a legitimate medical need

Although approved multi-agent chemotherapy regimens offer an incremental advance over single-agent treatments, the best available treatment cocktails are only marginally effective, and virtually all PDAC eventually becomes resistant to these treatments ( 1, 2 )

doi: 10.1080/1028415X.2020.1752996