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*Correspondence: Francesca Bugli [email protected] Iafisco [email protected] This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

One possible explanation for the clinical differences between RBD-PD and PD without RBD (non-RBD-PD) is the body-first and brain-first hypotheses of PD pathogenesis