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Open 4 , e2139558 (2021)

Free Radic Biol Med 36:12081213 Lee OH, Jain AK, Papusha V, Jaiswal AK (2007) An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance

There are strong familial links, with most patients having first-degree relatives with the disease, and recent genome-wide association studies have identified risk loci[6]