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The use of the highly selective and strong mGluR5 receptor antagonist (3-[2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine (MPEP) reduced reference and working memory in a radial arm maze task in rats [31]

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the present invention relates to a vaccine composition a vaccine composition comprising less than 10,000 pharmamers, such as for example less than 9,000, 8,000, 7,000, 6,000, 5,000, 4,000, 3,000, 2,000, 1 ,000, 900, 800, 700, 600, 500, 400, 300, 200, 100, 95, 90, 85, 80, 75, 70, 65, 60, 55, 50, 45, 40, 35, 30, 25, 20, 15, 10, 9, 8, 7, 6, 5, 4, 3, or less than 2 pharmamers