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Dichloroacetate (DCA): This small molecule inhibits pyruvate dehydrogenase kinase, promoting pyruvate entry into mitochondria and favoring OXPHOS over glycolysis

Moreover, DHA increased CREB phosphorylation and BDNF levels and attenuated neuroinflammation and oxidative stress, reflected by lower levels of IBA-1, IL-1, and IL-6 and increased levels of SOD1 and Nrf2