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The formation of apoptosome (cytochrome c, apoptotic protease-activating factor-1 (Apaf-1), and dATP/ATP) is the key of the intrinsic pathway

Audiol Res 13(3):441458 Domarecka E, Kalcioglu MT, Mutlu A, zgr A, Smit J, Olze H, Szczepek AJ (2021) Reporting data on auditory brainstem responses (ABR) in rats: recommendations based on review of experimental protocols and literature

doi: 10.1016/S2666-5247(24)00055-7 34 PelusoMJRyderDFlavellRRWangYLeviJLaFranchiBHet al

HSPs mitigate these deleterious effects by functioning as part of a broader free radical scavenger network, thereby reducing intracellular ROS accumulation and limiting oxidative damage (Fig