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demonstrated that the lactylation of cGAS is regulated primarily by AARS2, leading to the inactivation of cGAS, suppression of cGAMP synthesis, and inhibition of the innate immune response

Mol Cell 59 , 321332 (2015)

While knowing that thousands of genes are affected is fascinating, researchers want to understand exactly which genes are involved in this process

STMN2 is decreased following TARDBP knockdown due to altered splicing when TDP-43 is mislocalized and in motor neurons from patients and the spinal cord of postmortem samples

In the intestine, TGR5 activates enteroendocrine L cells, stimulating glucagon-like peptide-1 (GLP-1) secretion (74)