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Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells

PM2.5 suspended in the air can adsorb microorganisms and directly enter alveoli, markedly downregulating the activity of the anti-inflammatory factor miR-362-3p in alveolar epithelial cells and promoting the overexpression of the downstream target runt-related transcription factor 1 (RUNX1) of miR-362-3p, in which RUNX1 induces the transdifferentiation of fibroblasts into myofibroblasts, driving the occurrence of respiratory diseases, such as PF (107,108)

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J Intern Med 248(5):377386

Hsieh, J.-Y., Chen, M.-C